Someone who looks mental impaired or has a gormless look about them.

Refering to someone with Downs Syndrome - so really should be "downsie" It is a genetic condition that is increasingly common the older the mother of a child is when she falls pregnant. Downs Sydrome is caused by non disjunction of the 21st chromosome (humans have 23 pairs of chromosomes - each parent supplies 23 chromosomes to the child getting a total of 46) which means chromosome 21 in the mother has not split like it should when making sex cells (gametes) and the child ends up with 3 copies of chromosome 21 compared to the usual 2. Some characteristics of downs syndrome include:

Poor muscle tone
Slanting eyes with folds of skin at the inner corners (called epicanthal folds)
Hyperflexibility (excessive ability to extend the joints)
Short, broad hands with a single crease across the palm on one or both hands
Broad feet with short toes
Flat bridge of the nose
Short, low-set ears
Short neck
Small head
Small oral cavity
Short, high-pitched cries in infancy

Sufferers of Downs Syndrome are ussually smaller than their normal peers and their physical and intellectual development is ussually slower.

A derogatory term for someone with downs syndrome. a insult to someone who may act like they have downs syndrome, or just a dumb fuck

someone with down syndrome

slang for a person with down-syndrome

abreviated version of downsyndrome, refering to someone else who is either slow or does something stupid

someone who goes down on people...on friday

A word originating from Orlando, FL having a somewhat dual meaning in referring to a girl who frequents the downtown club and party scene and is essentially "down" for whatever, generally in terms of wild partying, sex, drugs, and alcohol abuse. While this word intially had derogatory connotations it has in many circles become a term of endearment, much like "bitch", "nigga", or "motherfucker".