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4.
A person, generally from the eastern hemisphere, who has been stricken with an extra twenty first chromesome given to them by their unloving mother. This extra inconvenience is refferred to as "Trisomy 21," and often forces the "downsy" to live a life working behind the scenes of carnivals (out of the public eye) and eating everybody's cookie dough.
Though I commited the crime, I blamed my downsy cousin and got him put behind bars where he belongs.
by Julio Sanchez August 28, 2005
 
1.
A term used to describe those with Down's Syndrome, who for some reason also have no facial hair.
My downsy cousin ate all of my fucking cookie dough.
by big d February 16, 2005
 
2.
A word meaning that you are "down" to do something;
You think something is a good idea, and you want to participate
Friend 1: Do you want to go to the party tonight?
Friend 2: Downsies
by jorman1 April 04, 2011
 
3.
Refering to someone with Downs Syndrome.It is a genetic condition that is increasingly common the older the mother of a child is when she falls pregnant. Downs Sydrome is caused by non disjunction of the 21st chromosome (humans have 23 pairs of chromosomes - each parent supplies 23 chromosomes to the child getting a total of 46) which means chromosome 21 in the mother has not split like it should when making sex cells (gametes) and the child ends up with 3 copies of chromosome 21 compared to the usual 2. Some characteristics of downs syndrome include:

Poor muscle tone
Slanting eyes with folds of skin at the inner corners (called epicanthal folds)
Hyperflexibility (excessive ability to extend the joints)
Short, broad hands with a single crease across the palm on one or both hands
Broad feet with short toes
Flat bridge of the nose
Short, low-set ears
Short neck
Small head
Small oral cavity
Short, high-pitched cries in infancy

Sufferers of Downs Syndrome are usually smaller than their normal peers and their physical and intellectual development is ussually slower.
"He looks like a downsy."
"Her brother is a downsy."
by [skorpion] May 25, 2006
 
5.
A negative word used by shallow and inconsiderate people to describe themselves or others when they a) look stupid or b) act stupid, because they think looking and acting dumb is a trademark sign of Down's syndrome. Used by people who have never met someone who actually has Down's syndrome, and who are ignorant of and insensitive to a serious condition.
Cassie: Ewww! I look so downsy in this facebook picture, haha. I look sooo gross! I'm untagging myself!
Anne: Um, you look fine.
Rob: Yeah, shut the fuck up. My sister has Down's syndrome.
by Rob and Sophie January 06, 2010