Top Definition
When you are really pissed off at someone who is normal(not retarded in anyway) and has a slightly down syndrome look face, you yell at them "what the fuck are you looking at, you down syndrome motherfucker!! This releases stress and puts a great big smile on your face. Try it today!
No examples needed for down syndrome motherfucker. You can fit it in with just about anything.
by Mr. Fuko February 18, 2011

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