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1.
The accelerated state of affliction of doucheness disease which has become irreversible and leads to complete social death.

or

Someone so completely immersed in doucheness, that they are automatically considered as a stand-by replacement for any member of the cast of Jersey Shore.
“you know, I saw Rick S. the other day, his douchethelioma is really bad now.”

"so we called Jeannie C. and pretended to be her doctor's office with her test results – when we told her she had a raging case of douchethelioma, she asked if it was curable and we told her it was terminal.”

“that fat skank Roseann could definitely replace Mangelina next season on Jersey Shore: Corpus Christi.”
by Jimmy from the Ville October 11, 2010