This is a non-offensive term most commonly used to replace the word "ass" and is often used as a term of annoyance. Can also be used to describe a very foolish or unintelligent individual. This term is purposely meant to not make any sense whatsoever.
"BUDDY, YOU'RE BEING A PAIN IN THE DOOPASHOE!!!"
"Wow, that guy is a total doopashoe."
"Quit being a doopashoe and get over here and help me with this."