Top definition
the aggravated state a man gets in when he has not received dome for an extended period of time
Quentin: holy fuck im about to kill someone
Dan: looks like you have dome syndrome. you just need some dome dude, chill out
by Barndon A. October 22, 2005
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2
The elitist inbred offspring of Notre Dame alumni.
ND Student 1: "Why is George Walker (8th generation legacy) a student here? He barely communicates in monosyllabic grunts. I thought you had to be a smart overachiever or at least a gifted athlete to get into the University of Notre Dame!"

ND Student 2: "Dude, He has dome syndrome."
by BKitty (class of 2012) October 22, 2008
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