"Mama dio can,xe pronto o no?!"
"Dio can ke goal ke me so magnà"
"Jaio dio can...refite!"
Dio can ke cagàda ke me scampa"
And more...and more...and more...DIO CAN!!!
In English holy shit or holy fuck.
However it is generally used as a way of expressing (1)disappointment, (2)anger and (3)surprise; even some Christians use it, obviously they don't mean to offend their god.
"Dio cane" I've got a bad mark in my test paper...
2. Dio cane ma vai via dalle palle ?!
"Dio cane" will you leave me alone ?!
3. Dio cane ma hai visto che esplosione ?!
"Dio cane" did you see that explosion ?!