To have multiple sexual partners
"And I'm hearin' you letting yo' health slide these days; and yo lady's dicked up, and you contracted to AIDS" -Ja Rule
by Cadbury The Wiseman October 10, 2013
to cause ones problems to become worse. to mess things up or fuck things up.
Dude, that test today dicked up my average in english class
by harmon April 08, 2006