Top Definition
Weed, ganja, cannabis sensamillia, marijuana, reefer, grass, pot.
No, I don't smoke the Devil's Lettuce, you Goddamn Hippie!
by jjthemick May 10, 2006

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Weed, Ganja Mary Jane etc.
That homeslice was all smoked up on the devils lettuce.
by sctso October 29, 2003

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Another word for: Cannabis, also known as marijuana, marihuana, and ganja (from Sanskrit: गांजा gañjā, meaning "hemp"), among many other namesa, refers to any number of preparations of the Cannabis plant intended for use as a psychoactive drug. The most common form of cannabis used as a drug is the dried herbal form.
The major psychoactive chemical compound in cannabis is Δ9-tetrahydrocannabinol (commonly abbreviated as THC).
Martin: I smell something weird down here. Smells like ya'll been hitting the Devil's lettuce

--- From The Heartbreak Kid (2007) Movie

Extended Synonyms: Weed, green(s), danks, pot, buddha or bud, Mary Jane, grass, herb, dope, schwag, grass, sac, nug, ihop, MJ, and reefer, are among the many other nicknames for marijuana or cannabis as a drug
by MOCHESTER April 15, 2010

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a slang term for marijuana. there is also weed, pot, reefer. etc. this list goes on, blah blah blah
"brad is such a pot head"
'yeah he really likes his devils lettuce, doesnt he?"
by lyzzieloo January 02, 2008

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Why its weed of course, you know, marijuana. Gets ya fucked up...like if lucifer himself were to stop by and toss your salad....
shit! this weed is the devils lettuce!
by SuperScooter February 28, 2009

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Another name for the sweet, sweet cheeba.
As Keith got Game of Thrones loaded up on the DVR, Dave packed a fat bowl of the devil's lettuce and prepared to get high as balls.
by Dstyles April 08, 2013

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A nickname of the drug Marijuana.
Used in a sentence-
"Jimmy be smokin' the Devil's Lettuce."
by Bananicus May 15, 2016

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