To have a retarded face, or expression causing others to find it funny, creepy or just plain stupid.
Ex. 1 Jennifer Lawrence is the queen of derp because of the faces she makes.

Ex. 2 "I'm bored."
"Me too."
*Awkward silence.*
"Derp."
"Yeah..."

Ex. 3 Jennifer Lawrence Queen of Derp trended on Twitter worldwide. (FACT)
by Swim-on-and-on-and-on.... September 07, 2012
When one is blazed and attempts to leave a party/chief session.
Yo guys, I gotta get home, boutta derp.
by dixon yamada October 01, 2011
a stupid act committed by an individual which is regretted in retrospect.
passing out with your shoes off at a party is considered a MAJOR derp
by ferral penguin June 26, 2011
An incurable disease, at least until the introduction of Duck Sauce's "Barbra Streisand" with a combination of yelling "Unf Unf Unf" between two mirrors.
Kindoflike Bloody Mary three times, but this one actually works. 50% of the time.

It is known to afflict a certain Jason Liu's face constantly (See "Jason Liu" for more information)

Commonly associated with "Herp"
DocMo: "Hi what's your name?"
Jason: "Derp"
DocMo: "Barbra Streisand"
Kenja: "UNFUNFUNF"
by kendaninjabinja May 02, 2011
The state of being cross-eyed and generally looking stupid, possibly with some showing of teeth for effect. Being derp can be voluntary or involuntary
You would be derp if you lost your retainer, were perplexed by something etc.
by Daraghderp November 13, 2010
N. 1.Epic fail. An attempt at something of extreme greatness, but an utter fail. Antonym: Herp. 2. An expression used in the act of failing, often an exclamation. 3. The name for someone/thing that has failed.

V. Sucking really hard.
N. 1.
1: That guy ate it so hard on that triple pirouette.

2: I know, right?! What a derp.

N. 2.
1(while belly-flopping into a pool): DERP!

N. 3.
1: You honestly tried to pull off cooking 30 brownies in 20 minutes? You fucking derp.

V.
1: Have you ever herped so hard you derped?
by RadioactivePuppy October 26, 2010
Indicating retardation in both speech and thought; incomprehensible guttoral sounds intended as English predominantly spoken in the South. See also Southern Accent
Southerner: "Derp-de-DERP! Twang, twannnggg......"

Northerner: "WTF did he just say???"

Southerner: "Derp-de-DOOOO!!! Heheheh!"

Northerner: "Fuck it, I'll find I-95 on a map. Thanks anyway."
by Buck_Turgidson October 05, 2010
A person who may catch you while you're doing something that you're not supposed to be doing.
Look out! It's a derp! RUN
by MSTJ September 27, 2010

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