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23.
To have a retarded face, or expression causing others to find it funny, creepy or just plain stupid.
Ex. 1 Jennifer Lawrence is the queen of derp because of the faces she makes.

Ex. 2 "I'm bored."
"Me too."
*Awkward silence.*
"Derp."
"Yeah..."

Ex. 3 Jennifer Lawrence Queen of Derp trended on Twitter worldwide. (FACT)
by Swim-on-and-on-and-on.... September 07, 2012
 
43.
Anything and everything. I can mean whatever you want it to be.
Person 1: What a derp.
Person 2: I know, he be derpin.
by whoopwhoopshawhoop95555 June 08, 2011
 
44.
The action of pure randomness and retardation.
Guy 1: My entire family just died!!!!
Guy 2:..........derp!
by itzadolfin!! May 10, 2011
 
45.
An incurable disease, at least until the introduction of Duck Sauce's "Barbra Streisand" with a combination of yelling "Unf Unf Unf" between two mirrors.
Kindoflike Bloody Mary three times, but this one actually works. 50% of the time.

It is known to afflict a certain Jason Liu's face constantly (See "Jason Liu" for more information)

Commonly associated with "Herp"
DocMo: "Hi what's your name?"
Jason: "Derp"
DocMo: "Barbra Streisand"
Kenja: "UNFUNFUNF"
by kendaninjabinja May 02, 2011
 
46.
Symbolizing a retarded face, look, etc., making fun of it.
Im the Joker, Batman! DERP!
by BATMAN DERP February 06, 2011
 
47.
Sound simultaneously expressing supreme dorkiness and excitement of boston terriers.
derp, derp, derp (repeat until satisfied)
by BT Supreme January 20, 2011
 
48.
a totally ridiculous person who abbreviates all their words and says that they have a ghat. popular sayings are nahnahnahnah and wanna die? Derps tend to live in basking ridge. subjects often say wheres ma ghat? they will also ask for qual rides to chip after prac whichs translates to quality ride to chipotle after practice. a list of common abbreviations are garb = garbage, ridic= ridiculous, imposs= impossible, ment= mental
Ridge Hockey Team, Derp Dan
by nyjets28 January 19, 2011
 
49.
10. Something obvious.
Person #1: What?

Person #2: I love you, that's what. Derp! :P
by Inaia December 18, 2010