A harsher method of referring to someone (or something) that frequently exhibits characteristics commonly seen as extremely "drenny," also referred to as "extremely nerdy" or any extreme adjectives of a similar nature. Dren
is commonly used as a less abrasive variation.
Note: Dern came into use by means of a misspelling of the original phrase, "dern." Since then it has become a harsher word and should be used only when circumstances do in fact warrant it.
"The name's Bond. Covalent Bond."
"You are such a dern!"