Top Definition
When a girl has one eye that is straight and the other one looks off center just like daphne in the old school scoobie doo cartoon. This often causes a confusion effect to the on-looker as they do not know which eyeball to focus on.
I had a hard time focusing on what she was saying because she suffers from such a bad case of the daphne syndrome.
by deano912 October 25, 2011

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