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1.
means to be good with ones hands in italian. In english it means babes cannot get enough of these hands.
so i was giving her the cusimano special and then she said , hey man thats my ear
by JJJC January 12, 2009
 
2.
A way of telling someone that they're fucked. When translated from Italian to English it says "cusick" a.k.a. see you sick. Usually shortened to "Cusi".
Person 1: I didn't study for my exams!

Person 2: Ha, cusimano.

Person 1: I know right.
by n00btr00per May 25, 2011