To mix alcohol and pills/weed/or any other drug.
FUCKS YOU UP!!!
Tony- Hey man- we finished that handle of tequila

Mike- Yeah i know, lets drink that fifth of gin

Tony- Lets take these flexeril first and get cross faded

______________________________________

next day-
mike- wtf happened, why am i in your drive way
tony- idk, i was on top of the shed
by Partystarter619 October 04, 2009

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Top Definition
To be drunk and high. This is the prefered method of getting faded for many.
I had five beers before lighting up a blunt then 4 more shots of Southern Comfort. I was hella cross faded.
by bendersd September 24, 2005

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Being intoxicated by one ore more concentrated substances at any given time. Most commonly Cannabis (Marijuana) and Ethanol (Alcohol)
The first time I got Crossfaded it was so intense, I almost couldn't handle it.
by MikeDeeFearing October 25, 2011

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Stoned and drunk at the same time.

Marijuana + Alcohol.
Pete was so cross-faded last night he fell asleep on top of his girlfriend during sex.
by Clouds07 July 25, 2013

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the act of getting high on marijuana and the holy spirit simultaneously
try this dank right here, its called Proverbs 4:20. you'll get so crossfaded you'll wake up 3 days later in a cave

my preacher is my dealer so you know I'm always crossfaded come sunday morning, praise the lord
by clarencewong March 18, 2015

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When you high as shit but shit faced drunk at the same time
I took 7 bong rips and 5 shots I was cross faded as fuck
by Little boy Johnny June 12, 2016

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The non-gay way to say "twisted"..The stage of being both high&drunk. Makes girls pass out and guys act like stupid fuckers who get really mad at everything. It feels better then anything but you just pass out for hours.
Asshole 1: look she passed out with her shoes on!! She's so crossfaded
Asshole 2: you know what that means!
Asshole1: let's fuck with her
Asshole 2: I'm down!!!
by Yesiloveweed1334 June 27, 2009

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