a drugs effects are wearing off (after smoking marijuana, this usually occurs about two hours later)
"hey, fire up the bowl again, i'm coming down"
by lauren August 31, 2003
The effect of sobering up from any drug. If its weed, things are speeding up back to normal. If its cystal meth, you feel like passing out, not enough energy.
"Pass the sh** man, m coming down here."
by HLT April 26, 2005