a drugs effects are wearing off (after smoking marijuana, this usually occurs about two hours later)

The effect of sobering up from any drug. If its weed, things are speeding up back to normal. If its cystal meth, you feel like passing out, not enough energy.

could be the worst effing thing in the universe.. to barely even noticing. in reference to a drug wearing off.. meth, weed, heroin, coke.. you name it.