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1.
a drugs effects are wearing off (after smoking marijuana, this usually occurs about two hours later)
"hey, fire up the bowl again, i'm coming down"
by lauren August 31, 2003
 
2.
The effect of sobering up from any drug. If its weed, things are speeding up back to normal. If its cystal meth, you feel like passing out, not enough energy.
"Pass the sh** man, m coming down here."
by HLT April 26, 2005
 
3.
could be the worst effing thing in the universe.. to barely even noticing. in reference to a drug wearing off.. meth, weed, heroin, coke.. you name it.
ahh shit.. i'm coming down!
by t May 07, 2005