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1.
to give up or to quit. to stop doing.
yo, that bitch need to come off that attitude for real.

you need to come off that dumb shit man and get with it.
by A6 from DeepBlue August 10, 2008
16 7
 
2.
to give or to release
She need to come off some shares of her startup company to her advisors.
by Rigo April 28, 2006
19 10