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2.
A slang term used in response towards an issuer of verbal threats and/or an aggressive posture, to indicate that the receiver of the threats is ready, willing and able to engage in physical combat, in an act of self-defense should the issuer of the threats wish to escalate the situation to a physical one. This slang term is normally used by people who are extremely confident in their ability to easily neutralize/subdue the aggressor. eg. Walk the walk, don't just talk the talk.
Hothead: Hey homeboy, yo mamma was gud' in bed last nite, haha!
Icecold: Come at me...

*Icecold knocks Hothead the fuck out with 1 punch to the jaw*

Icecold: You were sayin' bitch?
by TheTrooth December 07, 2011
 
1.
attack me
i aint affraid of you, bitch. come at me!
by JediUrsa April 21, 2004
 
3.
To approach, speak to, or interact with in any fashion.
Some broad didn't like the opinions on my web site, so she came at me all crazy talkin' mad trash in an e-mail.
by buddhablaze January 28, 2003