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To have one's Comcast cable internet service suddenly cease working at the worst possible time. Unlike it's root word, castrate, comcastration can (and is, in fact, likely to) happen over and over and over to both men and women.
I was just about to pay my credit card bill online when I got comcastrated, causing me to miss the midnight deadline and incurring $28 in late fees.
by blumer November 02, 2006