Top Definition
a major state road/highway that runs straight the the heart of the city of orlando and extends much further past, running east and west to each coast. state road 50. west colonial drive = ghetto, east colonial drive = not as ghetto, some very nice areas. colonial drive = the portion of state road 50 that runs through downtown, or used to refer to any particular portion of state road 50 in orange county, florida.
we headed to roxy to party last night
where's that?
it's on colonial drive and bennett, a little way east of downtown orlando.
by crunk407 March 27, 2008

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