1. A person who transports cocaine within their own body.
2. Being worked very hard and normally seeing little reward for your work.
3. Someone who you have control over (see bitch).
1. That coke mule had half a kilo in their ass.
2. My boss was running me like a coke mule today.
3. Bob is my coke mule.
on who hides cocaine up their rectum for smuggling it into another country or other area with tight security (jail, etc).
The coke mule made it across the border untouched, but had a hard time retrieving the swag.