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1.
A state of intense sadness, melancholia or despair that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living.
This state os often entered after being caught commiting acts that one would rather have not been caught doing.
My client has not comment to the allegations that have been brought forward as he is in a state of clinical depression.
by Alajjana August 31, 2007
 
2.
Depression that doctors actually care about.
patient: Docter, I'm depressed...

doctor: Is it clinical depression?

patient: No....

doctor: Get the fuck out of here then.
by bobrocks95 November 13, 2009
 
3.
The technical term for depression of clinical significance. Although depression is somewhat ambiguous, this usually refers to a long term struggle to cope with one's self, society and/or their environment.

Clinical depression usually revolves around the concept of brain chemistry according to most psychologists. Researchers insist some people may be predisposed or vulnerable to depression because their brain cannot produce enough monoamines such as serotonin, norepinephrine and dopamine. This is often referred to as a chemical imbalance by researchers. When a diagnosis for Clinical Depression is given with the cause being brain chemistry, doctors and psychiatrists will often start shoving various and often unnecessary prescriptions for antidepressant drugs at you. Although, most SSRI drug treatments are harmless and usually produce positive results, if a doctor gives you a prescription and you have had symptoms for less than a year, consider doing more research before you accept a prescription for SSRI drugs since doctors often hand these out like candy, and since pharmaceutical companies have had a major influence in depression research often sponsoring doctors and researchers.
1. "My psychiatrist has given me anti depressants for my legitimate and long term Clinical Depression and I feel good again! I have the motivation to move on with my life now."

2. "After 15 minutes of talking with a psychiatrist I was handed a prescription for a drug that could potentially kill me and give me seizures."
by Depression101 October 19, 2012
 
4.
The same exact thing as depression, but usually more severe. Fluffed up with the world 'clinical' to make the problem seem medical.
depressed person: im miserable

psychiatrist: oh no no no you have clinical depression

depressed person: fuck you who cares about your technicalities

psychiatrist: theres a totally different brain structure

depressed person: no there isnt you just made that up

psychiatrist: um...i dunno
by Shadow Creator October 11, 2007