Top definition
Charlie Brown syndrome is just bad luck. When nothing goes your way and whatever effort you do is slightly pathetic, that refers to Charlie Brown.
For example charlie brown syndrome, Charlie Brown could never kick that football because Lucie kept pulling it away from him. He never really had luck with the girl he liked, and things just never went his way. He also had a Christmas tree that was just sad.

As much as we like to root for the underdog Charlie Brown, he just can't get a break because of his bad luck.
by SkyCreation May 12, 2014
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2
It refers to when someone talks and all you hear is wah wah, wah wah, wah wah. Like when an adult talked to Charlie Brown in the cartoon.
She talks so much I get Charlie Brown syndrome every time we have a conversation. I never hear a word she says.
by Madstabber January 08, 2016
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