When a drug dealer/trafficker dismantles his operation and reestablishes it in another part of town or out of town. Involves finding new buyers and possibly new suppliers. Generally the result of a run in with police or a confrontation with a rival dealer. The intent is to avoid being killed or arrested.
Boosey’s girl snitched to the cops about those keys he was moving outta his mom’s house, so he has to change route.
From BG’s song Doing My Thang:
“Just as quick as I can open shop and move a brick out I change route,
I feel that vibe, I'm good at scoping shit out”.