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1.To Cock Block your friend from talking to or fucking a girl.
2. Preventing someone from getting in a girls pants.
You are at a bar talking to a girl and your friend jumps between the two of you and starts talking to her.

Girls can C-Block guys too by preventing them from getting in their girlfriend pants. Usually by making them leave with them instead of you.

C-Block by Notorious JRB June 21, 2006

M.A.C Block 

An area in the city of Vallejo, where only the true mac's are found hustling. It is located on the corner of Miller Ave (around the corner from Teeters and Smorga Bobs)
Its a mac thang...Biatch! M.A.C Block...Ya Know!!
M.A.C Block by MaCk So December 23, 2003
Also know as Cock-block. Commonly found at Fraternity party. Person A is talking to hot drunk chick, when his friend Person B comes up, equally as drunk and embarasses person A, to the point where drunk hot chick no longer wants to give up the buns.
"Dude, you cheesehead bastard. Why are u bringing up my sexual ineptitude in public?!? I could have SCORED!"
c-block by CoorsLightEMU April 20, 2003

C-Block Souljaz

A street gang representing the Cedarvale area of Toronto. Many casualties take place due to common altercations or "beefs". A C-Block Soulja is commonly seen robbing and/or beating down someone while doing numerous drugs and/or drinking alcoholic beverages.
Some Jamaican: Ayo wha gwon bombaross?!
C-Block Soulja: Shut the fuck up nigga fo I put this fifth up yo ass and let tha trigga do the talkin
Some Jamaican: Ya nah wan rump wit jamaica ya fossewol, we de original rostaclo---
BAP BAP BAP
C-Block Soulja: Ye, yous a smart mu'fucka now. Respec' yo'sef. I'm in the hood all day you should call me crack niggas. And we out 'fo one time come. ..
C-Block Souljaz by T. Dot. Ro June 20, 2005
the area in which all the BOOOOOOYS hang out at school, bunch of good cunts there, brotherhood.
Sanjay: you going to kick it at C BLOCK today at lunch bro?
Gulas: of course!
C BLOCK by bartyboy November 14, 2011
the area of Glen Ridge that is within a blocks distance of carteret park. basically where all the bros live
c block is where all the bros chill
c block by ChloePowell May 17, 2011