Top Definition
1) Origination: to do something with six of an object
2) Current: with extreme enthusiasm or extreme effort
Some girl: I felt so sick after eating Dentyne Ice by the sixes.
Some guy: Yeah, it didn't go very well with that beef jerky.
Other guy: Really? I thought it was great! We should totally do it again...
(All in unison): BY THE SIXES!!
by Edward I May 02, 2006

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