look up any word, like blumpkin:
 
1.
A less serious name for anal and/or colon cancer
Dr. Gupta: You have butthole cancer.

Mr. Larrity: What are you talking about?

Dr. Gupta: It affects 99% of CEOs and 100% of politicians at some point in their lives. We will have to remove your butthole before it spreads.
by ThomasGRogan November 26, 2009
 
2.
a more humorous form of colon cancer
johhny: dude, my gerbil just died. doc says its from colon cancer.
Johnny: wtf? how did he get butthole cancer?
by tallywacker June 10, 2008