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Fucking something up extremely, or not being able to focus.
Usually being said if something bad happens while under the influence of some kind of drug.
"Don't be buffalo, do bomb."
"James, you buffalo you broke my front door?!"
"Your being buffalo."
by Nic M. December 28, 2007
Noun: A handsome guy with a nice figure. Can refer to buff or slender guys. Soccer players and football players can both be buffalo.
Sara: Buffalo. 2 o'clock.
Sam: Dark hair?
Sara: I think his names Rob, total buffalo.
by charmingone:) November 22, 2010
Buffalo is a drinking game that you can only play if you agree to play for life. There's no blood contract, but there might as well be. The rules are as follow:
-A buffalo player must always hold his or her drink
in his or her non-dominant hand. If you are ambidextrous you must declare a hand of choice prior to entering the game (for life).
-a failure to follow the first rule results in the ability for another buffalo player to call "BUFFALO!" on you. At this point you must chug your entire beer.
-There are many caveats. If a beer is in your dominant hand and also placed on a table or on your shoulder, or if you manage to inconspicuously touch your drink with any part of your non-dominant hand, then if "BUFFALO" is called it doesn't count. This is known as a "false buffalo," and the offending false accuser must then chug their beer.
-Another occasion in which the "false buffalo" rule can be invoked is if you are double fisting. This creates many interesting scenarios, as you can attempt to trick people by holding a beer in your dominant hand while holding one in your other hand also, perhaps under the table, behind your back, maybe in the pocket of a hoodie. Both beers must be open and must contain at least some beer for it to be a "false buffalo," otherwise youve been the victim of a legit buffalo call. Inducing a false buffalo is generally more respected than calling a successful one.
-Athletes may wish to incorporate "water buffalo" to stay hydrated.

Player 2: "Fuck I'm gonna puke," or "False Buffalo!"
by El Capitan Monsiuer Bisch January 25, 2010
a random person not truly invited to a party; thereby, ruining the entire party
"Dude, I didn't know what to do! I was surrounded by buffalo EVERYWHERE!"
by Capt. Frat April 27, 2009
An African American woman who is very fat and very ugly.
I can't belive he married that buffalo. He can do so much better.
by Davy C August 10, 2007
v. To smoke an entire blunt to the face
Man I just buffaloed a 2 gram blunt and now I'm high as hell.
by Preeds December 20, 2005
Cows that look like bears
Dude, those cows look crazy! They look like bears! They've got their winter coats on for sure... Or, maybe they're buffalo... That's why they look like bears...
by Madd-Dogg Andersen November 30, 2010
Asides from a large hairy mammal, a city in northwestern New York, and a verb meaning "to bully or intimidate", apparently now a meme on 4chan.
"Gullible Wordfilters to Buffalo!"

"How buffalo do you think I am? Srsly!"
by lancelot323 September 03, 2008