Top Definition
Any event where you get drunk. I don't mean just drunk. I mean DRUNK. When your common sense and your BAC play a game of chicken, and the common sense loses-drunk.

Also can be used to refer to a party, concert, night or any event where this activity takes place en masse.
Get Todd some aspirin. He committed a pretty hefty brain cell genocide last night.

Tanya's wedding ceremony was beautiful, but the reception was a brain cell genocide. Like, we're talkin' Rwanda-bad. Gray matter holocaust.
by Darren C March 26, 2008
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