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1.
1) Quite possibly any health problem you can have.

2) Any unexplained illness or injury.
Holy Fuck, Jules got botulism from all that curry!
by Rhombus of Love August 17, 2005
 
2.
flesh-eating form of food poisoning, usually resulting from eating Ben's cooking, can result in decomposition, making the sufferer technically a living cadaver
Luke: Bloody nora i've got a bit of the old BOTULISM - i'll never eat one of Ben's bacon sandwiches again; oh bugger my leg's fell off - felch!
by Ben and Luke May 23, 2008
 
3.
another way of saying "lame", "stupid", etc.
"that is like, SO botulism."
by shadylady1234 November 13, 2009