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1.
To administer a psychoactive drug rectally.
Idiot: Booty bumping tweak is awesome!

Idiot with deathwish: Stop being stupid. It's all about mainlining.
by Not an idiot July 10, 2006
 
2.
when one shakes ones ass against another's ass and vibrations in between would result in a booty bumping.
"I was shaking my thang, when this chick suddenly grinding in my space booty bumping."
by Jaysin and ahmanduh August 28, 2009