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1.
(noun) - a hollowed out philly blunt filled with weed.

(verb) - to smoke a weed.
- to be really high
Hey man you got some bleo in your room?

Its 4:20 lets bleo.

I need to sit down and bleod.
by Mr. Bleo August 26, 2004
 
2.
Short for Bleomycin, one of the widest spread drugs used as part of chemotherapy against certain forms of cancer
Gotta take my weekly dose of Bleo
by SirViver August 03, 2009