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An extremely large bomb, often nuclear.
During the Cold War the United States was afraid that the Soviets would drop the big one.
by blenheimears April 14, 2009
one thousand dollars
I just bet two big ones on black jack.
by Teemuh April 30, 2008
a pleasantly large penis
I think my cervix is dented ... he has a BIGONE!
by carefulgirl September 12, 2006
code for a bundle of heroin- 10 bags, otherwise known as a bun
i copped a big one for eighty in paterson and flipped it for a buck twenny to some maricóns in westchester
by nothing where we go December 31, 2010