A massive fart released from the anus that may cause nauseousness.
Chad ripped a Big One in Kiersten's face while she was giving him his morning blow!
by SlopNChop November 26, 2016
one thousand dollars
I just bet two big ones on black jack.
by Teemuh April 30, 2008
An extremely large bomb, often nuclear.
During the Cold War the United States was afraid that the Soviets would drop the big one.
by blenheimears April 14, 2009
a pleasantly large penis
I think my cervix is dented ... he has a BIGONE!
by carefulgirl September 12, 2006
code for a bundle of heroin- 10 bags, otherwise known as a bun
i copped a big one for eighty in paterson and flipped it for a buck twenny to some maricóns in westchester
by nothing where we go December 31, 2010