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1.
the nigga that put you in yo set or gang
random nigga: thats the blood that offered to jump you in right?
Damu(blood member): ya thats my big homie.
by Monsta Quake August 01, 2008
 
2.
Slang term used in California, mainly L.A. area to call someone, a friend, dawg, loc, or gang member.
The Big Homie got the whole block locked gee...he be on that blue rag shit...
by real15 October 08, 2008