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1.
Friends who are so good together that there is no other description word to use beside awesome. They have a bond like you wouldn't believe. Generally boy-girl friendships. May be a friends with benefits type situation, but not always. This is the kind of friendship that makes significant others get suspicious.
Person one: Jon and Natalie are totally awesomefriends.

Person two: Yeah, I hear they do all sorts of weird romantic shit together, but it's not really serious.

Person one: Natalie's boyfriend must be so jel.
by electric-sex-in-the-window November 07, 2012
 
2.
A friend who is really awesome
She's my awesomefriend.
by Dangdude1 August 12, 2011