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1.
A mole on your ass. Similar to asshole. But since the asshole serves a purpose for excretory purposes, an assmole is purely a skin defect on your ass.
STFU ASSMOLE!
Your mom gave birth to an assmole :D
by Failedxattempts May 21, 2008
 
2.
A combo of asshole and mole used to describe a female that you dislike.
Man i hate tina, she is an ass-mole
by 2345432545324534332455435454 August 14, 2007