Top Definition
A disease in which the patient acts like an asshole, talks like an asshole, does asshole things and has asshole stuff
If you cut me off with that fancy car you have just get chicks with, you might have Assholiosis
by boomboombow March 08, 2015

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Plagued by incurable assholiness. (see: "assholiness")
His whole family suffers from assholiosis. His dad got drunk and passed out at my wedding after making a toast and confusing my name with my husband's ex-girlfriend's. His cousin was voted "most likely to win a Darwin award" in 5th grade. And his brother came onto me at his own wedding.
by BPS1966 July 01, 2014

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