1) One person of many sprinkled about the face of the Earth by god to test the patience of those who believe in him. Most of which are relatives
or live in your city.

2) A broke person with no job and who you helped out and you gave them a place to sleep and you gave them food and they let your indoor cat out and they smoked your stash and they ate ALL of your food and used the last of your toilet paper and fell asleep in your favorite chair and pissed in it ... ... ... and gets mad when you kick them out but doesn't forget to ask for a ride somewhere.

Your current boss.

someone being arrogant, rude, obnoxious, or just a total dickhead....

Your butt hole. Were your shit comes out.

A person in another car who cuts you off to get to the next lane, almost hits you while talking on the phone.

An obnoxious, arrogant, self-centered male who women can't seem to get enough of.

Anyone who doesn't do exactly what you think they ought to do, exactly when you think they ought to do it.

The worst kind of person. You cannot fully construct a meaning that fully encompasses what this vicious insult means. If you're an asshole, you are disgusting, loathesome, vile, distasteful, wrathful, belligerent, agoraphobic, and more. Assholes are human fecal matter. They are the lowest of the low. They transcend all forms of immorality. It is the very worst of insults; to be called an asshole is to have your very soul ripped apart and shat on. I say that the word "asshole" is the worst cussword of the english language, worst than fuck, shit, and cunt combined.