to murder (esp. a politically important or prominent person) by surprise attack, usually for payment or from zealous belief
to harm or ruin (someone's reputation, etc.), as by slander, vilification, etc.
- your mission is too asses....assiss...assas...TO KILL A GUY (top gun version)
Powerful people fear that someone will try to assassinate them.
To kill someone wearing 700 lb armor by smacking them with the handle of your gun.
"What the hell, I shot someone in the chest with a sniper rifle and he didn't die, and by the time I could shoot him again someone assassinated me."
To fuck someone in the ass so hard for so long that they literally die.
I fucked your Mom... balls deep in the ass... for 24 hours straight... until she died.
I ass-assinated her!
To do your best to really kill a girl (sexually). A popular cheer from your boys who happen to be watching.
"Hey, I'm 'bout to go assassinate that pussy!" or "Yo, man, assassinate that shit!! Kill it!"