Top Definition
Refers to going mental over something in a completely unrestrained way, or getting beyond pissed off at something. Refers to an episode of Degrassi Junior High where Shane drops acid at a "Gourmet Scum" concert, trips balls, and jumps off a bridge, causing brain damage.
1)That party was so much fun, I went apeshit on acid.
2)I don't want to go apeshit on acid on you, but what you did was weaksauce, man.
by hotseat June 20, 2007
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