Top Definition
An anti-smile is a facial expression caused by excessive consumption of ecstacy or mdma. The anti-smile will usually manifest itself during the come-down period - the person appears to be smiling upside down.
1. Matey must be off his box, look at that anti-smile.

2. Oi bruv, wat wrong with your mate?
Nothin, hes just anti-smiling

3. How chiseled is ya boy? Look at his anti-smile
by Oggzy blau March 30, 2007
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