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1.
To reduce to a state of non-existance. To remove all trace of. Destruction in its ultimate form.
I annihilated that mysterious butt itch with one scratch.
by tt February 16, 2003
 
2.
Kill, destroy, obliterate, decimate, eradicate, smash, crush, beat the living shit out of... all good examples of annihilation, must I say more?
What I will do to you if you don't go away.
by Your Momma In A Two Piece December 13, 2004
 
3.
to destroy completely
i will annihilate your family.
by amberjeffrey January 05, 2009
 
4.
what the lord did to egypt... antibody-anni nile(river) hi-high late as dead(annile-hi-late)!?
Moses(mo says) used plagues to annihilate egypt.
by Marc Edenfield September 29, 2007
 
5.
To Fuck the shit out of a girl
I annihilated her ass last night!
by chino Fresh April 30, 2006
 
6.
1. To reduce to nothing, to destroy, to eradicate.

2. The action garlic (the vegetable) has on pretty much anything threatening to a living body's health.
i was getting sick a few weeks back and i just ate and ate garlic and it annihilated (from Annihilate ) what ever it was I was getting"
by cnm1802 March 22, 2009
 
7.
Common slang on "Jackass" for injury, usually by the Pennsylvannia boys (Ryan, Bam, Brandon, etc...)
"I'm Ryan Dunn and I'm about to be towed through some haggard corn fields here and get annihilated."
by trixter1138 September 05, 2003