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1.
A white tablet devised by Bayer Industries to finally solve the world's pigeon problems. Also known as "pigeon killer".
I gave alka-seltzer to a pigeon and it exploded.
by Rommel Rico August 15, 2006
 
2.
Perhaps the best icebreaker ever made. It consists of Taking alka-seltzer, dropping it into a woman's drink, it fizzing, and her asking "is that Roofies?"
You-drop alka-seltzer into cup
Woman- what the fuck did you just roofie me?
You-Pull out alka-seltzer and explain its just that

she might then say something along the lines of "Oh my Gosh that is so funny we should have sex right now"

...your welcome
by TheRuralThesaurus1 October 24, 2010
 
3.
When you drop your balls into somebody's carbonated beverage. When dropped in, they make the sound "plop plop. fizz fizz", much like the advertisement for the original product.
Dude, go over there and alka-seltzer that guy's drink.
by triculous April 30, 2011
 
4.
The act of taking a duece while in a hot tub. Since the hot tub is already churning water, bubbles, and blowing hot water, the turd will quickly dissolve like an alka-seltzer, leaving a nice fecal coloring to the water.
I was in Laura's hot tub last night, listening to Aaron Neville, and sippin' on a chilled glass of white zinfandale, when I decided to leave an alka-seltzer.
by Miami Matt September 02, 2006