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1.
AIDS.

Acquired immune deficiency syndrome is a disease which is slow and painful to kill.

Its also a weight loss drug found commonly in Africa.

FAIL.

To fall short of success or achievement in something expected, attempted, desired, or approved.

AIDS and FAIL.

Combine the two and you get a creamy delicious filling of slow and painful death by ones own incompetence and/or stupidity.
Jimmy: "I just posted up a new youtube video to my myspace account of me having sex with my stuffed toy collection!

Tommy: "Dude that shit is so lame that it's filled with AIDS and FAIL!"
by MortisNai March 08, 2008
 
2.
A complete and utter lack of goodness and or decency. See Daikatana
"That game is made of Aids and Fail."
by ChadAvant March 24, 2008