Top Definition
A cyst that also has many of the same characteristics of a zit. Often seen as a large raised redish area on the skin.
Elliot wants to pop the zyst on his neck, but he really should see a doctor instead.
by DoWhat? August 25, 2009
n. A giant, angry, throbing, pus-filled bump; part zit, part cyst
My blind date was a nice enough guy but, I was fearful that the zyst on his face could erupt at any moment!
by tboone March 13, 2010
The crappy new name of RSC king/queen Mystress.
"Mystress' new name sucks...who would want the name Zyst?"
by ~ December 16, 2004

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