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2.
Zydrate is a fictional drug. In the movie Repo! The Genetic Opera, Zydrate -a potent opioid extracted from dead bodies- is manufactured by GeneCo. as a prescription painkiller. Zydrate is injected with a Zydrate-Gun which uses an electric current to enhance the drug's analgesic effect.
Graverobber: Zydrate comes in a little glass vile.

Shilo: A little glass vile?

Junkies: A little glass vile!

Graverobber: And the little glass vile goes into the gun like a battery... And the Zydrate-Gun goes somewhere against your anatomy... And when the gun goes off it sparks and you're ready for surgery.
by LJenna January 05, 2009
 
1.
It's an essence extracted from someone's skull at the point of death.

It's highly euphoric and addictive. You don't feel anything while it's inside of you.

Amber Sweet (Paris Hilton) is addicted to it in Repo! The Genetic Opera. She has a sexual relationship with G-Rob who she gets it from.

It's generally used before getting surgery.

Though, it's highly abused.
(From Zydrate Anatomy)
GRAVEROBBER
Zydrate comes in a little glass vial.

SHILO
A little glass vial?

CROWD
A little glass vial!

GRAVEROBBER
And the little glass vial goes into the gun like battery.
And the Zydrate gun goes somewhere against your anatomy
And when the gun goes off, it sparks and you're ready for surgery.
by NoahtheGreat September 17, 2008
 
3.
A mixture of Mountain Dew Voltage and ecstasy (MDMA). Named after and inspired by the fictional drug of the same name from the movie Repo! The Genetic Opera.
Hey dude, I made some zydrate from some ecstasy we got at the club the other night.
by Jehav July 02, 2009
 
4.
Zydrate is a rare type of drug that helps relieve pain. It also gets you a bit high. Mainly scalpel sluts use this drug.
Amber Sweet is addicted to the knife, so in order for her to relieve her pain, she buys Zydrate from a Grave Robber.
by xxRepoManxx October 03, 2008