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1.
An exclamation of surprise typically expressing fear or dismay.
Shaggy sees the ghost coming toward him, shouts "Zoiks", and runs the other direction.
by jillianb October 10, 2006
 
2.
To described something in the superlative form.
Zoiks=WOW!!!
All was said was "zoiks" as the beautiful girl walked by.
by Hank0001 June 03, 2004