A disease that causes intense swelling of the head and ego. Effects also include arrogance, condescension, and an inability to see one's faults.

Caution: May cause loss of friends and a brown nose.

(See also: Pretentious douche; insufferable know-it-all)
"Man that kid gets on my nerves- he thinks he knows everything."
-"Yeah, he has Zeb Syndrome"
by crunchywookiee May 29, 2012

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