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1.
Yes in a happy or excited way.
"So you get to go biking today?" Josh asked. "Yupo", I answered.
by Kelly (Beagleluvr) March 27, 2008
 
2.
A recently discovered form of Yup. Used when agreeing to a crazy idea weather its good or bad
So Are you going to the City Tomorrow?
Yupo
by DJ Torres May 23, 2006
 
3.
a phrase to express extreme certainty in cases dealing with the opposite sex, or pig races.
"Hey are you gonna go to the beach with all those girls?"
"Yupo"

"Number 4 won the race?"
"Yupo"
by Mike n' Parker July 12, 2004
 
4.
yupo: I don't know
Person A: So when's that football game?
Person B: Yupo.
by anonymous history February 10, 2008